The Atlanta Falcons host the Detroit Lions on Oct. 26 at 9:30 a.m. ET, with the game televised on Fox.
"We are excited about playing three regular-season games in the UK for the first time and debuting a new game time that we expect to be a hit with fans on both sides of the Atlantic and around the world," NFL chief marketing officer Mark Waller said in a statement.
The Oakland Raiders host the Miami Dolphins on Sept. 28 at 1 p.m. ET on CBS and the Jacksonville Jaguars host the Dallas Cowboys on Nov. 9 at 1 p.m. ET on Fox.
Each of the International Series games will be played at Wembley Stadium.