In a battle of unbeaten teams Friday night in Knoxville, Greeneville fell behind early and couldn't stop Knox-Fulton's high-powered offense, losing for the first time this season, 40-20.
The Fulton Falcons scored first, a Penny Smith to Xavier Hawkins touchdown connection for a 7-0 lead.
The Greene Devils fell behind 13-0, but then Quan Wilson got them on the board with a seven-yard touchdown run.
In the second quarter, Smith hit Hawkins on a screen and the speedy wide receiver did the rest, burning Greeneville's defense for a 21-7 lead. Fulton led 28-7 at halftime.
Wilson added another short touchdown run for the Greene Devils in the third to get them closer, 28-13.
Late in the third, Greeneville tried a fake punt, but Fulton wasn't fooled, stopping it and later turning the turnover into a touchdown with a De'Ontay Tate 22-yard scamper.
"You have to play almost perfect against them," Greeneville head coach Caine Ballard told News 5 WCYB.
"You can't start bad against them either, couldn't overcome it. It was an unbelievable season. It is getting tough up there to accept twelve wins, but twelve wins is huge."
"Hopefully everybody still understands these young man laid it out there to get those wins night after night. We're certainly happy about that."
Greeneville finishes the season 12-1. Knox-Fulton advances to face Knox-Catholic.